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J. Bacteriol., Nov 1997, 6862-6864, Vol 179, No. 21
Copyright © 1997, American Society for Microbiology

SigmaE is an essential sigma factor in Escherichia coli

A De Las Penas, L Connolly and CA Gross
Department of Bacteriology, University of Wisconsin-Madison, 53706, USA.

SigmaE is an alternative sigma factor that controls the extracytoplasmic stress response in Escherichia coli. SigmaE is essential at high temperatures but was previously thought to be nonessential at temperatures below 37 degrees C. We present evidence that sigmaE is an essential sigma factor at all temperatures. Cells lacking sigmaE are able to grow at low temperatures because of the presence of a frequently arising, unlinked suppressor mutation.


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