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J. Bacteriol., Apr 1997, 2319-2330, Vol 179, No. 7
Copyright © 1997, American Society for Microbiology

Transcription of genes encoding DNA replication proteins is coincident with cell cycle control of DNA replication in Caulobacter crescentus

RC Roberts and L Shapiro
Department of Developmental Biology, Stanford University School of Medicine, California 94305-5427, USA.

DNA replication in the dimorphic bacterium Caulobacter crescentus is tightly linked to its developmental cell cycle. The initiation of chromosomal replication occurs concomitantly with the transition of the motile swarmer cell to the sessile stalked cell. To identify the signals responsible for the cell cycle control of DNA replication initiation, we have characterized a region of the C. crescentus chromosome containing genes that are all involved in DNA replication or recombination, including dnaN, recF, and gyrB. The essential dnaN gene encodes a homolog of the Escherichia coli beta subunit of DNA polymerase III. It is transcribed from three promoters; one is heat inducible, and the other two are induced at the transition from swarmer to stalked cell, coincident with the initiation of DNA replication. The single gyrB promoter is induced at the same time point in the cell cycle. These promoters, as well as those for several other genes encoding DNA replication proteins that are induced at the same time in the cell cycle, share two sequence motifs, suggesting that they represent a family whose transcription is coordinately regulated.


This article has been cited by other articles:

  • Jensen, R. B., Shapiro, L. (2003). Cell-Cycle-Regulated Expression and Subcellular Localization of the Caulobacter crescentus SMC Chromosome Structural Protein. J. Bacteriol. 185: 3068-3075 [Abstract] [Full Text]  
  • Keiler, K. C., Shapiro, L. (2003). tmRNA in Caulobacter crescentus Is Cell Cycle Regulated by Temporally Controlled Transcription and RNA Degradation. J. Bacteriol. 185: 1825-1830 [Abstract] [Full Text]  
  • Keiler, K. C., Shapiro, L. (2001). Conserved Promoter Motif Is Required for Cell Cycle Timing of dnaX Transcription in Caulobacter. J. Bacteriol. 183: 4860-4865 [Abstract] [Full Text]  
  • Ward, D. V., Newton, A. (1999). Cell Cycle Expression and Transcriptional Regulation of DNA Topoisomerase IV Genes in Caulobacter. J. Bacteriol. 181: 3321-3329 [Abstract] [Full Text]  
  • Marczynski, G. T. (1999). Chromosome Methylation and Measurement of Faithful, Once and Only Once per Cell Cycle Chromosome Replication in Caulobacter crescentus. J. Bacteriol. 181: 1984-1993 [Abstract] [Full Text]  


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