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J. Bacteriol., 04 1997, 2435-2439, Vol 179, No. 7
Copyright © 1997, American Society for Microbiology

Unfolding of the bacterial nucleoid both in vivo and in vitro as a result of exposure to camphor

EW Harrington and NJ Trun
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

Both prokaryotic and eukaryotic cells are sensitive to killing by camphor; however, the mechanism by which camphor kills has not been elucidated. We report here that camphor unfolds the nucleoid of Escherichia coli and that unfolding does not require DNA replication, translation, or cell division. We show that exposure of isolated nucleoids to camphor results in unfolding of the chromosome.

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