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Vol. 180, Issue 13, 3477-3479, July 1, 1998

NOTE
Characterization of the Earliest Known Staphylococcus aureus Plasmid Encoding a Multidrug Efflux System

Ian T. Paulsen, Melissa H. Brown, and Ronald A. Skurray

School of Biological Sciences, University of Sydney, Sydney, New South Wales 2006, Australia

The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.

Copyright © 1998 by American Society for Microbiology


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