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Journal of Bacteriology, September 1998, p. 4621-4627, Vol. 180, No. 17
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Only the N-Terminal Domain of FtsK Functions in Cell Division

G. Craig Draper, Neil McLennan, Ken Begg, Millicent Masters, and William D. Donachie*

Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland

Received 18 February 1998/Accepted 26 June 1998

Deletion of ftsK results in the inhibition of cell division, but this inhibition can be reversed by a plasmid carrying only the first ~17% of ftsK. The division block can be suppressed in most mutants by deletion of dacA, which codes for the D-alanine:D-alanine carboxypeptidase PBP5, or in all mutants by overexpression of ftsN. Overexpression of ftsK inhibits cell division and the formation of FtsZ rings. This division block is not due to the induction of either the SOS or the heat shock regulons.

* Corresponding author. Mailing address: ICMB, University of Edinburgh, Darwin Building, King's Buildings, Mayfield Rd., Edinburgh EH9 3JR, Scotland. Phone: 44 0131 650 5354. Fax: 44 0131 668 3870. E-mail: William.Donachie{at}ed.ac.uk.

Journal of Bacteriology, September 1998, p. 4621-4627, Vol. 180, No. 17
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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