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Journal of Bacteriology, December 1998, p. 6338-6341, Vol. 180, No. 23
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Methionine Induces Sexual Development in the Fission Yeast Schizosaccharomyces pombe via an ste11-Dependent Signalling Pathway

Anne-Marie Schweingruber, Norma Hilti, Eleonore Edenharter, and M. Ernst Schweingruber*

Institute of General Microbiology, University of Bern, CH-3012 Bern, Switzerland

Received 13 July 1998/Accepted 16 September 1998

Methionine added to minimal medium overcomes the repressing effects of ammonium and cyclic AMP (cAMP) on sexual development and efficiently induces mating and sporulation in homothallic strains of Schizosaccharomyces pombe. In heterothallic strains it induces G1 arrest when cells enter stationary phase. We show that methionine reduces the intracellular cAMP pool and induces the expression of at least two cAMP-repressible genes, including fbp1 and ste11. The easiest interpretation of the results is that methionine induces sexual development via a cAMP-dependent ste11 signalling pathway.

* Corresponding author. Mailing address: Institute of General Microbiology, University of Bern, Baltzer-Strasse 4, CH-3012 Bern, Switzerland. Phone: (41-31) 631 46 58. Fax: (41-31) 631 46 84. E-mail: sgruber{at}imb.unibe.ch.

Journal of Bacteriology, December 1998, p. 6338-6341, Vol. 180, No. 23
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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