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Journal of Bacteriology, December 1998, p. 6415-6418, Vol. 180, No. 23
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Family of Stability Determinants in Pathogenic Bacteria

Finbarr Hayes*

Microbiology Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, England

Received 7 August 1998/Accepted 23 September 1998

A novel segregational stability system was identified on plasmid R485, which originates from Morganella morganii. The system is composed of two overlapping genes, stbD and stbE, which potentially encode proteins of 83 and 93 amino acids, respectively. Homologs of the stbDE genes were identified on the enterotoxigenic plasmid P307 from Escherichia coli and on the chromosomes of Vibrio cholerae and Haemophilus influenzae biogroup aegyptius. The former two homologs also promote plasmid stability in E. coli. Furthermore, the stbDE genes share homology with components of the relBEF operon and with the dnaT gene of E. coli. The organization of the stbDE cassette is reminiscent of toxin-antitoxin stability cassettes.

* Present address: Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology (UMIST), P.O. Box 88, Manchester M60 1QD, England. Phone: 44-(0)161-2004200. Fax: 44-(0)161-2360409. E-mail: Finbarr.hayes{at}mail.bi.umist.ac.uk.

Journal of Bacteriology, December 1998, p. 6415-6418, Vol. 180, No. 23
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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