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Journal of Bacteriology, December 1998, p. 6773-6775, Vol. 180, No. 24
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Mutant of Mycobacterium smegmatis Defective in Dipeptide Transport

Achal Bhatt,1 Renee Green,1 Roswell Coles,1 Michael Condon,3 and Nancy D. Connell1,2,*

Department of Microbiology and Molecular Genetics1 and National Tuberculosis Center,2 Department of Medicine, and Department of Surgery,3 UMDNJ/New Jersey Medical School, Newark, New Jersey 07103

Received 1 July 1998/Accepted 14 October 1998

A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine (beta -alanyl-L-histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on beta -Ala and/or L-His were similar in the mutant and the wild type. However, the mutant showed significant impairment in the uptake of carnosine. This study is the first description of a peptide utilization mutant of a mycobacterium.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, UMDNJ/New Jersey Medical School, 185 South Orange Ave., Newark, NJ 07103. Phone: (973) 972-3759. Fax: (973) 972-3644. E-mail: connell{at}umdnj.edu.

Journal of Bacteriology, December 1998, p. 6773-6775, Vol. 180, No. 24
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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