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J Bacteriol, February 1998, p. 892-900, Vol. 180, No. 4
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Coordination of Initiation of Nuclear Division and Initiation of Cell Division in Schizosaccharomyces pombe: Genetic Interactions of Mutations

A. Grallert,1 B. Grallert,1,dagger B. Ribar,1,Dagger and M. Sipiczki1,2,*

Department of Genetics1 and Institute of Biology,2 University of Debrecen, Debrecen, Hungary

Received 30 September 1997/Accepted 9 December 1997

sep1+ encodes a Schizosaccharomyces pombe homolog of the HNF-3/forkhead family of the tissue-specific and developmental gene regulators identified in higher eukaryotes. Its mutant allele sep1-1 causes a defect in cytokinesis and confers a mycelial morphology. Here we report on genetic interactions of sep1-1 with the M-phase initiation mutations wee1-, cdc2-1w, and cdc25-22. The double mutants sep1-1 wee1- and sep1-1 cdc2-1w form dikaryon cells at high frequency, which is due to nuclear division in the absence of cell division. The dikaryosis is reversible and suppressible by cdc25-22. We propose that the genes wee1+, cdc2+, cdc25+, and sep1+ form a regulatory link between the initiation of mitosis and the initiation of cell division.

* Corresponding author. Mailing address: Department of Genetics, University of Debrecen, P.O. Box 56, H-4010 Debrecen, Hungary. Phone: 36-52-316-666/2404. Fax: 36-52-348-550. E-mail: lipovy{at}tigris.klte.hu.

dagger Present address: Department of Cell Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway.

Dagger Present address: Department of Pediatrics, University of Debrecen, H-4012 Debrecen, Hungary.




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