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J Bacteriol, March 1998, p. 1256-1260, Vol. 180, No. 5
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The spoIIE Locus Is Involved in the Spo0A-Dependent Switch in the Location of FtsZ Rings in Bacillus subtilis

Anastasia Khvorova,dagger Ling Zhang,Dagger Michael L. Higgins, and Patrick J. Piggot*

Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140

Received 22 September 1997/Accepted 16 December 1997

A switch in the location of FtsZ ring structures from medial to polar is one of the earliest morphological indicators of sporulation in Bacillus subtilis. This switch can be artificially caused during vegetative growth by induction of an active form, Sad67, of the transcription regulator, Spo0A (P. A. Levin and R. Losick, Genes Dev. 10:478-488, 1996). We have used immunofluorescence microscopy to show that the switch in FtsZ ring location during vegetative growth caused by Sad67 induction is blocked by a spoIIE deletion mutation. The spoIIE mutation also impaired polar FtsZ ring formation during sporulation. These results suggest that SpoIIE mediates the Spo0A-directed formation of polar FtsZ rings.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140. Phone: (215) 707-7927. Fax: (215) 707-7788. E-mail: piggotp{at}astro.ocis.temple.edu.

dagger Present address: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO.

Dagger Present address: Department of Microbiology, SmithKline Beecham, Collegeville, PA.




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