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Journal of Bacteriology, June 1999, p. 3610-3612, Vol. 181, No. 11
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Salmonella typhimurium IroN and FepA Proteins Mediate Uptake of Enterobactin but Differ in Their Specificity for Other Siderophores

Wolfgang Rabsch,1 Wolfgang Voigt,1 Rolf Reissbrodt,1 Renée M. Tsolis,2 and Andreas J. Bäumler3,*

National Reference Center for Salmonellae and Other Enterics, Robert Koch-Institute, D-38855 Wernigerode, Germany1; Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-44672; and Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University Health Science Center, College Station, Texas 77843-11143

Received 19 January 1999/Accepted 25 March 1999

Salmonella typhimurium possesses two outer membrane receptor proteins, IroN and FepA, which have been implicated in the uptake of enterobactin. To determine whether both receptors have identical substrate specificities, fepA and iroN mutants and a double mutant were characterized. While both receptors transported enterobactin, the uptake of corynebactin and myxochelin C was selectively mediated by IroN and FepA, respectively.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M Univ. Hlth. Sci. Ctr., 407 Reynolds Medical Building, College Station, TX 77843-1114. Phone: (409) 862-7756. Fax: (409) 845-3479. E-mail: abaumler{at}tamu.edu.

Journal of Bacteriology, June 1999, p. 3610-3612, Vol. 181, No. 11
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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