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Journal of Bacteriology, June 1999, p. 3833-3836, Vol. 181, No. 12
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Role for the oxyS Gene in Regulation of Intracellular Hydrogen Peroxide in Escherichia coli

Beatriz González-Flecha1,* and Bruce Demple2

Physiology Program, Department of Environmental Health,1 and Division of Toxicology, Department of Cancer Cell Biology,2 Harvard School of Public Health, Boston, Massachusetts 02115

Received 25 January 1999/Accepted 8 April 1999

Intracellular hydrogen peroxide is regulated in Escherichia coli by OxyR in response to the metabolic production of H2O2. Here, we show that the untranslated oxyS RNA controlled by OxyR has a role in this regulation. The oxyS transcript appears to affect the metabolic output of H2O2 rather than the removal of H2O2 by catalases-hydroperoxidases.

* Corresponding author. Mailing address: Physiology Program, Department of Environmental Health, 665 Huntington Ave., Boston, MA 02115. Phone: (617) 432-1277. Fax: (617) 432-0014. E-mail: bgonzale{at}hsph.harvard.edu.

Journal of Bacteriology, June 1999, p. 3833-3836, Vol. 181, No. 12
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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