This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ren, Z.
Right arrow Articles by Stull, T. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ren, Z.
Right arrow Articles by Stull, T. L.

 Previous Article  |  Next Article 

Journal of Bacteriology, September 1999, p. 5865-5870, Vol. 181, No. 18
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Role of CCAA Nucleotide Repeats in Regulation of Hemoglobin and Hemoglobin-Haptoglobin Binding Protein Genes of Haemophilus influenzae

Zhen Ren,1,2 Hongfan Jin,1,2,dagger Paul W. Whitby,1 Daniel J. Morton,1 and Terrence L. Stull1,2,*

Departments of Pediatrics1 and Microbiology/Immunology,2 University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104

Received 19 April 1999/Accepted 12 July 1999

Haemophilus influenzae utilizes hemoglobin and hemoglobin-haptoglobin as heme sources. The H. influenzae hemoglobin- and hemoglobin-haptoglobin binding protein genes, hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. Using an hgpA-lacZ translational gene fusion, we demonstrate phase-variable expression of lacZ associated with alteration in the length of the CCAA repeat region.

* Corresponding author. Mailing address: Department of Pediatrics, CHO 2308, University of Oklahoma Health Sciences Center, 940 N.E. 13th St., Oklahoma City, OK 73104. Phone: (405) 271-4401. Fax: (405) 271-8710. E-mail: Terrence-Stull{at}ouhsc.edu.

dagger Present address: Department of Genetics, University of Wisconsin---Madison, Madison, WI 53706.

Journal of Bacteriology, September 1999, p. 5865-5870, Vol. 181, No. 18
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Nepluev, I., Afonina, G., Fusco, W. G., Leduc, I., Olsen, B., Temple, B., Elkins, C. (2009). An Immunogenic, Surface-Exposed Domain of Haemophilus ducreyi Outer Membrane Protein HgbA Is Involved in Hemoglobin Binding. Infect. Immun. 77: 3065-3074 [Abstract] [Full Text]  
  • King, M. R., Vimr, R. P., Steenbergen, S. M., Spanjaard, L., Plunkett, G. III, Blattner, F. R., Vimr, E. R. (2007). Escherichia coli K1-Specific Bacteriophage CUS-3 Distribution and Function in Phase-Variable Capsular Polysialic Acid O Acetylation. J. Bacteriol. 189: 6447-6456 [Abstract] [Full Text]  
  • Morton, D. J., Seale, T. W., Madore, L. L., VanWagoner, T. M., Whitby, P. W., Stull, T. L. (2007). The haem-haemopexin utilization gene cluster (hxuCBA) as a virulence factor of Haemophilus influenzae. Microbiology 153: 215-224 [Abstract] [Full Text]  
  • Srikhanta, Y. N., Maguire, T. L., Stacey, K. J., Grimmond, S. M., Jennings, M. P. (2005). The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes. Proc. Natl. Acad. Sci. USA 102: 5547-5551 [Abstract] [Full Text]  
  • Morton, D. J., Smith, A., Ren, Z., Madore, L. L., VanWagoner, T. M., Seale, T. W., Whitby, P. W., Stull, T. L. (2004). Identification of a haem-utilization protein (Hup) in Haemophilus influenzae. Microbiology 150: 3923-3933 [Abstract] [Full Text]  
  • Rohde, K. H., Dyer, D. W. (2004). Analysis of Haptoglobin and Hemoglobin-Haptoglobin Interactions with the Neisseria meningitidis TonB-Dependent Receptor HpuAB by Flow Cytometry. Infect. Immun. 72: 2494-2506 [Abstract] [Full Text]  
  • Bosch, M., Garrido, M. E., Llagostera, M., Perez de Rozas, A. M., Badiola, I., Barbe, J. (2002). Characterization of the Pasteurella multocida hgbA Gene Encoding a Hemoglobin-Binding Protein. Infect. Immun. 70: 5955-5964 [Abstract] [Full Text]  
  • Napierala, M., Parniewski, P., Pluciennik, A., Wells, R. D. (2002). Long CTG{middle dot}CAG Repeat Sequences Markedly Stimulate Intramolecular Recombination. J. Biol. Chem. 277: 34087-34100 [Abstract] [Full Text]  
  • Cope, L. D., Love, R. P., Guinn, S. E., Gilep, A., Usanov, S., Estabrook, R. W., Hrkal, Z., Hansen, E. J. (2001). Involvement of HxuC Outer Membrane Protein in Utilization of Hemoglobin by Haemophilus influenzae. Infect. Immun. 69: 2353-2363 [Abstract] [Full Text]  
  • Simpson, W., Olczak, T., Genco, C. A. (2000). Characterization and Expression of HmuR, a TonB-Dependent Hemoglobin Receptor of Porphyromonas gingivalis. J. Bacteriol. 182: 5737-5748 [Abstract] [Full Text]  
  • Cope, L. D., Hrkal, Z., Hansen, E. J. (2000). Detection of Phase Variation in Expression of Proteins Involved in Hemoglobin and Hemoglobin-Haptoglobin Binding by Nontypeable Haemophilus influenzae. Infect. Immun. 68: 4092-4101 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»