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Journal of Bacteriology, October 1999, p. 6176-6178, Vol. 181, No. 19
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Resistance to Bacitracin as Modulated by an Escherichia coli Homologue of the Bacitracin ABC Transporter BcrC Subunit from Bacillus licheniformis

Yael Meller Harel,1,* Adriana Bailone,1 and Eitan Bibi2

Institut Curie, Batiment 110, Centre Universitaire, F-91405 Orsay, France,1 and Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel2

Received 29 March 1999/Accepted 13 July 1999

A small open reading frame from the Escherichia coli chromosome, bcrCEC, encodes a homologue to the BcrC subunit of the bacitracin permease from Bacillus licheniformis. We show that disruption of the chromosomal bcrCEC gene causes bacitracin sensitivity and, conversely, that BcrCEC confers bacitracin resistance when expressed from a multicopy plasmid.

* Corresponding author. Mailing address: Institut Curie, Batiment 110, Centre Universitaire, F-91405 Orsay, France. Phone: 33 1 69 86 31 26. Fax: 33 1 69 86 31 25. E-mail: meller{at}curie.u-psud.fr.

Journal of Bacteriology, October 1999, p. 6176-6178, Vol. 181, No. 19
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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