This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Muñoz, R.
Right arrow Articles by García, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muñoz, R.
Right arrow Articles by García, E.

 Previous Article  |  Next Article 

Journal of Bacteriology, October 1999, p. 6214-6219, Vol. 181, No. 19
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of the Type 8 Capsular Gene Cluster of Streptococcus pneumoniae

Rosario Muñoz,1,2 Marta Mollerach,1,3 Rubens López,1 and Ernesto García1,*

Centro de Investigaciones Biológicas, CSIC,1 and Pharma Mar,2 Madrid, Spain, and Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina3

Received 7 June 1999/Accepted 20 July 1999

The complete nucleotide sequence of the capsular gene cluster (cap8) responsible for the biosynthesis of the capsular polysaccharide of Streptococcus pneumoniae type 8 has been determined. The cap8 gene cluster, located between the genes dexB and aliA, is composed of 12 open reading frames. A 14.7-kb DNA fragment embracing the cap8 genes was sufficient to transform an unencapsulated type 3 S. pneumoniae strain to a strain with the type 8 capsule. A possible scenario for the evolution of pneumococcal types 2 and 8 is outlined.

* Corresponding author. Mailing address: Centro de Investigaciones Biológicas, CSIC, Velázquez 144, 28006 Madrid, Spain. Phone: (34) 81-5611800. Fax: (34) 91-5627518. E-mail: e.garcia{at}cib.csic.es.

Journal of Bacteriology, October 1999, p. 6214-6219, Vol. 181, No. 19
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Mavroidi, A., Aanensen, D. M., Godoy, D., Skovsted, I. C., Kaltoft, M. S., Reeves, P. R., Bentley, S. D., Spratt, B. G. (2007). Genetic Relatedness of the Streptococcus pneumoniae Capsular Biosynthetic Loci. J. Bacteriol. 189: 7841-7855 [Abstract] [Full Text]  
  • Knoshaug, E. P., Ahlgren, J. A., Trempy, J. E. (2007). Exopolysaccharide Expression in Lactococcus lactis subsp. cremoris Ropy352: Evidence for Novel Gene Organization. Appl. Environ. Microbiol. 73: 897-905 [Abstract] [Full Text]  
  • Mavroidi, A., Godoy, D., Aanensen, D. M., Robinson, D. A., Hollingshead, S. K., Spratt, B. G. (2004). Evolutionary Genetics of the Capsular Locus of Serogroup 6 Pneumococci. J. Bacteriol. 186: 8181-8192 [Abstract] [Full Text]  
  • McEllistrem, M. C., Noller, A. C., Visweswaran, S., Adams, J. M., Harrison, L. H. (2004). Serotype 14 Variants of the France 9V-3 Clone from Baltimore, Maryland, Can Be Differentiated by the cpsB Gene. J. Clin. Microbiol. 42: 250-256 [Abstract] [Full Text]  
  • van Selm, S., van Cann, L. M., Kolkman, M. A. B., van der Zeijst, B. A. M., van Putten, J. P. M. (2003). Genetic Basis for the Structural Difference between Streptococcus pneumoniae Serotype 15B and 15C Capsular Polysaccharides. Infect. Immun. 71: 6192-6198 [Abstract] [Full Text]  
  • Waite, R. D., Penfold, D. W., Struthers, J. K., Dowson, C. G. (2003). Spontaneous sequence duplications within capsule genes cap8E and tts control phase variation in Streptococcus pneumoniae serotypes 8 and 37. Microbiology 149: 497-504 [Abstract] [Full Text]  
  • van Selm, S., Kolkman, M. A. B., van der Zeijst, B. A. M., Zwaagstra, K. A., Gaastra, W., van Putten, J. P. M. (2002). Organization and characterization of the capsule biosynthesis locus of Streptococcus pneumoniae serotype 9V. Microbiology 148: 1747-1755 [Abstract] [Full Text]  
  • Hardy, G. G., Magee, A. D., Ventura, C. L., Caimano, M. J., Yother, J. (2001). Essential Role for Cellular Phosphoglucomutase in Virulence of Type 3 Streptococcus pneumoniae. Infect. Immun. 69: 2309-2317 [Abstract] [Full Text]  
  • Jiang, S.-M., Wang, L., Reeves, P. R. (2001). Molecular Characterization of Streptococcus pneumoniae Type 4, 6B, 8, and 18C Capsular Polysaccharide Gene Clusters. Infect. Immun. 69: 1244-1255 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»