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Journal of Bacteriology, November 1999, p. 6840-6843, Vol. 181, No. 21
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Identification and Disruption of lisRK, a Genetic Locus Encoding a Two-Component Signal Transduction System Involved in Stress Tolerance and Virulence in Listeria monocytogenes

Paul D. Cotter,1 Nathan Emerson,1 Cormac G. M. Gahan,1,2 and Colin Hill1,2,*

Department of Microbiology1 and National Food Biotechnology Centre,2 University College Cork, Cork, Ireland

Received 12 July 1999/Accepted 25 August 1999

lisRK encodes a two-component regulatory system in the food pathogen Listeria monocytogenes LO28. Following identification of the operon in an acid-tolerant Tn917 mutant, a deletion in the histidine kinase component was shown to result in a growth phase variation in acid tolerance, an ability to grow in high ethanol concentrations, and a significant reduction in virulence.

* Corresponding author. Mailing address: Department of Microbiology, University College Cork, Cork, Ireland. Phone: 353-21-902397. Fax: 353-21-903101. E-mail: c.hill{at}ucc.ie.

Journal of Bacteriology, November 1999, p. 6840-6843, Vol. 181, No. 21
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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