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Journal of Bacteriology, April 1999, p. 2252-2256, Vol. 181, No. 7
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Oxygen Depletion-Induced Dormancy in Mycobacterium bovis BCG

Amanda Lim, Marianne Eleuterio, Bernd Hutter, Bernadette Murugasu-Oei, and Thomas Dick*

Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore

Received 9 November 1998/Accepted 19 January 1999

Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and alpha -crystallin-like protein and is sensitive to metronidazole.

* Corresponding author. Mailing address: Institute of Molecular and Cell Biology, 30 Medical Dr., Singapore 117609, Republic of Singapore. Phone: 65-874-3745. Fax: 65-779-1117. E-mail: mcbtd{at}imcb.nus.edu.sg.

Journal of Bacteriology, April 1999, p. 2252-2256, Vol. 181, No. 7
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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