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Journal of Bacteriology, April 1999, p. 2302-2306, Vol. 181, No. 7
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of mdcR, a Regulatory Gene of the Malonate Catabolic System in Klebsiella pneumoniae

Hwei-Ling Peng,1 Sheng-Ru Shiou,2 and Hwan-You Chang2,*

Institute of Biological Science and Technology, National Chiao Tung University,1 and Department of Life Science, National Tsing Hua University,2 Hsin Chu, Taiwan, Republic of China

Received 28 September 1998/Accepted 15 January 1999

The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region of mdcR, PmdcR, indicating a negative autoregulatory control.

* Corresponding author. Mailing address: Department of Life Science, National Tsing Hua University, 101 Kuang-Fu Road Sec. 2, Hsin Chu, Taiwan, Republic of China. Phone: 886-3-5742910. Fax: 886-3-5715934. E-mail: hychang{at}life.nthu.edu.tw.

Journal of Bacteriology, April 1999, p. 2302-2306, Vol. 181, No. 7
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Maddocks, S. E., Oyston, P. C. F. (2008). Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins. Microbiology 154: 3609-3623 [Abstract] [Full Text]  
  • Koo, J. H., Cho, I. H., Kim, Y. S. (2000). The Malonate Decarboxylase Operon of Acinetobacter calcoaceticus KCCM 40902 Is Regulated by Malonate and the Transcriptional Repressor MdcY. J. Bacteriol. 182: 6382-6390 [Abstract] [Full Text]  


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