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Journal of Bacteriology, April 1999, p. 2640-2642, Vol. 181, No. 8
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Cyclic AMP Can Decrease Expression of Genes Subject to Catabolite Repression in Saccharomyces cerevisiae

Oscar Zaragoza, Chris Lindley,dagger and Juana M. Gancedo*

Instituto de Investigaciones Biomédicas "Alberto Sols," CSIC-UAM, 28029 Madrid, Spain

Received 7 December 1998/Accepted 1 February 1999

External cyclic AMP (cAMP) hindered the derepression of gluconeogenic enzymes in a pde2 mutant of Saccharomyces cerevisiae, but it did not prevent invertase derepression. cAMP reduced nearly 20-fold the transcription driven by upstream activation sequence (UAS1FBP1) from FBP1, encoding fructose-1,6-bisphosphatase; it decreased 2-fold the activation of transcription by UAS2FBP1. Nuclear extracts from cells derepressed in the presence of cAMP were impaired in the formation of specific UASFBP1-protein complexes in band shift experiments. cAMP does not appear to act through the repressing protein Mig1. Control of FBP1 transcription through cAMP is redundant with other regulatory mechanisms.

* Corresponding author. Mailing address: Instituto de Investigaciones Biomédicas, Arturo Duperier 4, 28029 Madrid, Spain. Phone: 34-91-5854622. Fax: 34-91-5854587. E-mail: jmgancedo{at}iib.uam.es.

dagger Present address: School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

Journal of Bacteriology, April 1999, p. 2640-2642, Vol. 181, No. 8
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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