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Journal of Bacteriology, July 2000, p. 3843-3845, Vol. 182, No. 13
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Positive Correlation between Virulence of Pseudomonas aeruginosa Mutants in Mice and Insects

Georg Jander,1,dagger Laurence G. Rahme,2 and Frederick M. Ausubel1,*

Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital,1 and Department of Surgery, Harvard Medical School, and Shriner's Burns Institute, Massachusetts General Hospital,2 Boston, Massachusetts 02114

Received 19 January 2000/Accepted 10 April 2000

Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.

* Corresponding author. Mailing address: Department of Molecular Biology, Massachusetts General Hospital, 50 Blossom St., Boston, MA 02114. Phone: (617) 726-5969. Fax: (617) 726-5949. E-mail: ausubel{at}frodo.mgh.harvard.edu.

dagger Present address: Cereon Genomics, Inc., Cambridge, MA 02139.

Journal of Bacteriology, July 2000, p. 3843-3845, Vol. 182, No. 13
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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