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Journal of Bacteriology, July 2000, p. 3877-3880, Vol. 182, No. 13
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Organization and Cell-Cell Interaction in Starved Saccharomyces cerevisiae Colonies

Mazal Varon and Mordechai Choder*

Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv 69978, Israel

Received 16 February 2000/Accepted 20 April 2000

Cell growth in yeast colonies is a complex process, the control of which is largely unknown. Here we present scanning electron micrographs of Saccharomyces cerevisiae colonies, showing changes in the pattern of cell organization and cell-cell interactions during colony development. In young colonies (<= 36 h), cell density is relatively low, and the cells seem to divide in a random orientation. However, as the colonies age, cell density increases and the cells seem to be oriented in a more orderly fashion. Unexpectedly, cells in starved colonies form connecting fibrils. A single connecting fibril 180 ± 50 nm wide is observed between any two neighboring cells, and the fibrils appear to form a global network. The results suggest a novel type of communication between cells within a colony that may contribute to the ability of the community to cope with starvation.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv 69978, Israel. Phone: (972)-36409030. Fax: (972)-36409407. E-mail: lcchoder{at}post.tau.ac.il.

Journal of Bacteriology, July 2000, p. 3877-3880, Vol. 182, No. 13
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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