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Journal of Bacteriology, August 2000, p. 4654-4657, Vol. 182, No. 16
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) Transferase of Legionella pneumophila Transfers Two Kdo Residues to a Structurally Different Lipid A Precursor of Escherichia coli

Werner Brabetz,* Christiane E. Schirmer, and Helmut Brade

Research Center Borstel, Center for Medicine and Biosciences, Division of Medical and Biochemical Microbiology, D-23845 Borstel, Germany

Received 22 February 2000/Accepted 25 May 2000

The 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase gene of Legionella pneumophila was cloned and sequenced. Despite remarkable structural differences in lipid A, the gene complemented a corresponding Escherichia coli mutant and was shown to encode a bifunctional enzyme which transferred 2 Kdo residues to a lipid A acceptor of E. coli.

* Corresponding author. Mailing address: Research Center Borstel, Center for Medicine and Biosciences, Department of Medical and Biochemical Microbiology, Parkallee 22, D-23845 Borstel, Germany. Phone: 49-4537-188488. Fax: 49-4537-188686. E-mail: wbrabetz{at}fz-borstel.de.

Journal of Bacteriology, August 2000, p. 4654-4657, Vol. 182, No. 16
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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