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Journal of Bacteriology, September 2000, p. 4995-4997, Vol. 182, No. 17
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The rel Gene Is Essential for In Vitro Growth of Staphylococcus aureus

Daniel Gentry,* Tong Li,dagger Martin Rosenberg, and Damien McDevitt

SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426

Received 22 February 2000/Accepted 6 June 2000

The stringent response in Staphylococcus aureus is mediated by the nucleotide guanosine pentaphosphate, whose synthesis is catalyzed by the product of the rel gene. We report here that the rel gene is essential for the in vitro growth of S. aureus, distinguishing it from all other bacteria tested for this requirement.

* Corresponding author. Mailing address: SmithKline Beecham Pharmaceuticals, 1250 S. Collegeville Rd., Collegeville, PA 19426. Phone: (610) 917-7504. Fax: (610) 917-7901. E-mail: dan_r_gentry{at}sbphrd.com.

dagger Present address: PharmaNet Inc., Blue Bell, PA 19422.

Journal of Bacteriology, September 2000, p. 4995-4997, Vol. 182, No. 17
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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