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Journal of Bacteriology, November 2000, p. 6254-6258, Vol. 182, No. 21
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

A Second Allele of eppA in Borrelia burgdorferi Strain B31 Is Located on the Previously Undetected Circular Plasmid cp9-2

Jennifer C. Miller,1 James L. Bono,2,dagger Kelly Babb,1 Nazira El-Hage,1 Sherwood Casjens,3 and Brian Stevenson1,*

Department of Microbiology and Immunology, University of Kentucky College of Medicine, Lexington, Kentucky 40536-02981; Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 598402; and Division of Molecular Biology and Genetics, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 841323

Received 22 March 2000/Accepted 16 August 2000

Although sequence analysis of Borrelia burgdorferi isolate B31 was recently declared "complete," we found that cultures of this strain can contain a novel 9-kb circular plasmid, cp9-2. The newly described plasmid contains both sequence similarities with and differences from the previously identified B31 plasmid cp9-1 (formerly cp9). cp9-1 and cp9-2 each encode a unique allele of EppA, a putative membrane protein synthesized by B. burgdorferi during mammalian infection.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, MS 415 Chandler Medical Center, University of Kentucky College of Medicine, Lexington, KY 40536-0298. Phone: (859) 257-9358. Fax: (859) 257-8994. E-mail: bstev0{at}pop.uky.edu.

dagger Present address: U.S. Meat Animal Research Center, U.S. Department of Agriculture, Clay Center, NE 68933-0166.

Journal of Bacteriology, November 2000, p. 6254-6258, Vol. 182, No. 21
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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