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Journal of Bacteriology, February 2000, p. 829-832, Vol. 182, No. 3
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Increased Sensitivity to Oxidative Challenges Associated with topA Deletion in Escherichia coli

Yuk-Ching Tse-Dinh*

Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595

Received 6 April 1999/Accepted 8 November 1999

Deletion of topA in Escherichia coli was found to result in a higher level of killing after treatment with either hydrogen peroxide or N-ethylmaleimide. This effect on oxidative challenge response represents a new role for E. coli DNA topoisomerase I in addition to prevention of excessive negative supercoiling of DNA.

* Mailing address: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595. Phone: (914) 594-4061. Fax: (914) 594-4058. E-mail: yuk-ching_tse-dinh{at}nymc.edu.

Journal of Bacteriology, February 2000, p. 829-832, Vol. 182, No. 3
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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