This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Revill, W. P.
Right arrow Articles by Hopwood, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Revill, W. P.
Right arrow Articles by Hopwood, D. A.

 Previous Article  |  Next Article 

Journal of Bacteriology, June 2001, p. 3526-3530, Vol. 183, No. 11
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.11.3526-3530.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

beta -Ketoacyl Acyl Carrier Protein Synthase III (FabH) Is Essential for Fatty Acid Biosynthesis in Streptomyces coelicolor A3(2)

W. Peter Revill,* Maureen J. Bibb, Ann-Karolin Scheu,dagger Helen J. Kieser, and David A. Hopwood

John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom

Received 4 December 2000/Accepted 14 March 2001

The Streptomyces coelicolor fab (fatty acid biosynthesis) gene cluster (fabD-fabH-acpP-fabF) is cotranscribed to produce a leaderless mRNA transcript. One of these genes, fabH, encodes a ketoacyl synthase III that is essential to and is proposed to be responsible for initiation of fatty acid biosynthesis in S. coelicolor.

* Corresponding author. Present address: Kosan Biosciences, 3832 Bay Center Pl., Hayward, CA 94545. Phone: (510) 732-8400. Fax: (510) 732-8401. E-mail: revill{at}kosan.com.

dagger Present address: C/García Morato no. 14, 28805-Alcalá de Henares, Madrid, Spain.

Journal of Bacteriology, June 2001, p. 3526-3530, Vol. 183, No. 11
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.11.3526-3530.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Wang, J., Kodali, S., Lee, S. H., Galgoci, A., Painter, R., Dorso, K., Racine, F., Motyl, M., Hernandez, L., Tinney, E., Colletti, S. L., Herath, K., Cummings, R., Salazar, O., Gonzalez, I., Basilio, A., Vicente, F., Genilloud, O., Pelaez, F., Jayasuriya, H., Young, K., Cully, D. F., Singh, S. B. (2007). Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc. Natl. Acad. Sci. USA 104: 7612-7616 [Abstract] [Full Text]  
  • Bode, H. B., Ring, M. W., Kaiser, D., David, A. C., Kroppenstedt, R. M., Schwar, G. (2006). Straight-Chain Fatty Acids Are Dispensable in the Myxobacterium Myxococcus xanthus for Vegetative Growth and Fruiting Body Formation.. J. Bacteriol. 188: 5632-5634 [Abstract] [Full Text]  
  • Young, K., Jayasuriya, H., Ondeyka, J. G., Herath, K., Zhang, C., Kodali, S., Galgoci, A., Painter, R., Brown-Driver, V., Yamamoto, R., Silver, L. L., Zheng, Y., Ventura, J. I., Sigmund, J., Ha, S., Basilio, A., Vicente, F., Tormo, J. R., Pelaez, F., Youngman, P., Cully, D., Barrett, J. F., Schmatz, D., Singh, S. B., Wang, J. (2006). Discovery of FabH/FabF Inhibitors from Natural Products. Antimicrob. Agents Chemother. 50: 519-526 [Abstract] [Full Text]  
  • Li, Y., Florova, G., Reynolds, K. A. (2005). Alteration of the Fatty Acid Profile of Streptomyces coelicolor by Replacement of the Initiation Enzyme 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH). J. Bacteriol. 187: 3795-3799 [Abstract] [Full Text]  
  • He, X., Reeve, A. M., Desai, U. R., Kellogg, G. E., Reynolds, K. A. (2004). 1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH). Antimicrob. Agents Chemother. 48: 3093-3102 [Abstract] [Full Text]  
  • Lai, C.-Y., Cronan, J. E. (2003). {beta}-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is Essential for Bacterial Fatty Acid Synthesis. J. Biol. Chem. 278: 51494-51503 [Abstract] [Full Text]  
  • Cerdeno-Tarraga, A. M., Efstratiou, A., Dover, L. G., Holden, M. T. G., Pallen, M., Bentley, S. D., Besra, G. S., Churcher, C., James, K. D., De Zoysa, A., Chillingworth, T., Cronin, A., Dowd, L., Feltwell, T., Hamlin, N., Holroyd, S., Jagels, K., Moule, S., Quail, M. A., Rabbinowitsch, E., Rutherford, K. M., Thomson, N. R., Unwin, L., Whitehead, S., Barrell, B. G., Parkhill, J. (2003). The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129. Nucleic Acids Res 31: 6516-6523 [Abstract] [Full Text]  
  • He, X., Reynolds, K. A. (2002). Purification, Characterization, and Identification of Novel Inhibitors of the {beta}-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) from Staphylococcus aureus. Antimicrob. Agents Chemother. 46: 1310-1318 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»