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Journal of Bacteriology, June 2001, p. 3531-3535, Vol. 183, No. 11
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.11.3531-3535.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multiple Mobile Promoter Regions for the Rare Carbapenem Resistance Gene of Bacteroides fragilis

I. Podglajen,1 J. Breuil,2 A. Rohaut,1 C. Monsempes,1 and E. Collatz1,*

INSERM E0004-Laboratoire de Recherche Moléculaire sur les Antibiotiques, UFR Broussais-Hôtel Dieu and Pitié Salpétrière, Université Paris VI, Paris,1 and Laboratoire de Bactériologie, Centre Hospitalier Intercommunal, Villeneuve-Saint Georges,2 France

Received 30 October 2000/Accepted 20 March 2001

Two novel insertion sequences (IS), IS1187 and IS1188, are described upstream from the carbapenem resistance gene cfiA in strains of Bacteroides fragilis. Mapping, with the RACE procedure, of transcription start sites of cfiA in these and two other previously reported IS showed that transcription of this rarely encountered gene is initiated close to a variety of B. fragilis consensus promoter sequences, as recently defined (D. P. Bayley, E. R. Rocha, and C. J. Smith, FEMS Microbiol. Lett. 193:149-154, 2000). In the cases of IS1186 and IS1188, these sequences overlap with putative Esigma 70 promoter sequences, while in IS942 and IS1187 such sequences can be observed either upstream or downstream of the B. fragilis promoters.

* Corresponding author. Mailing address: INSERM E0004-LRMA, Université Paris VI, 15, rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. Phone: 33-1 42 34 68 65. Fax: 33-1 43 25 68 12. E-mail: collatz{at}ccr.jussieu.fr.

Journal of Bacteriology, June 2001, p. 3531-3535, Vol. 183, No. 11
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.11.3531-3535.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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