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Journal of Bacteriology, August 2001, p. 4914-4917, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4914-4917.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Autoamplification of a Two-Component Regulatory System Results in "Learning" Behavior

Sally M. Hoffer,1 Hans V. Westerhoff,2 Klaas J. Hellingwerf,3 Pieter W. Postma,3 and Jan Tommassen1,*

Department of Molecular Microbiology and Institute for Biomembranes, Utrecht University, 3584 CH Utrecht,1 Department of Molecular Cell Physiology, Free University, 1081 HV Amsterdam,2 and Swammerdam Institute for Life Sciences, University of Amsterdam,1018 WS Amsterdam,3 The Netherlands

Received 26 February 2001/Accepted 22 May 2001

We have tested the hypothesis that the autoamplification of two-component regulatory systems results in "learning" behavior, i.e., that bacteria respond faster or more extensively to a signal when a similar signal has been perceived in the past. Indeed, the induction of alkaline phosphatase activity upon phosphate limitation was faster if the cultures had been limited for phosphate previously, and this faster response correlated with the autoamplification of the cognate two-component system.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. Phone (31) 30 2532999. Fax (31) 30 2513655. E-mail: J.P.M.Tommassen{at}bio.uu.nl.

Journal of Bacteriology, August 2001, p. 4914-4917, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4914-4917.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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