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Journal of Bacteriology, October 2001, p. 5709-5717, Vol. 183, No. 19
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.19.5709-5717.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Genome of the Bacterium Streptococcus pneumoniae Strain R6

JoAnn Hoskins,1 William E. Alborn Jr.,1 Jeffrey Arnold,2 Larry C. Blaszczak,1 Stanley Burgett,2 Bradley S. DeHoff,2 Shawn T. Estrem,1 Lori Fritz,2 Dong-Jing Fu,2 Wendy Fuller,2 Chad Geringer,2 Raymond Gilmour,1 Jennifer S. Glass,1 Hamid Khoja,1 Angelika R. Kraft,1 Robert E. Lagace,3 Donald J. LeBlanc,1 Linda N. Lee,1 Elliot J. Lefkowitz,4 Jin Lu,1 Patti Matsushima,1 Scott M. McAhren,2 Margaret McHenney,2 Kevin McLeaster,2 Christopher W. Mundy,2 Thalia I. Nicas,1 Franklin H. Norris,2 MaryJeanne O'Gara,1 Robert B. Peery,1 Gregory T. Robertson,1 Pamela Rockey,2 Pei-Ming Sun,1 Malcolm E. Winkler,1 Yong Yang,1 Michelle Young-Bellido,1 Genshi Zhao,1 Christopher A. Zook,1 Richard H. Baltz,1 S. Richard Jaskunas,1 Paul R. Rosteck Jr.,2 Paul L. Skatrud,1 and John I. Glass1,*

Infectious Diseases Research and Clinical Investigation1 and Biological Research Technologies and Proteins,2 Eli Lilly and Company, Indianapolis, Indiana 46285; Incyte Genomics, Palo Alto, California, 943043; and Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 352944

Received 20 June 2001/Accepted 13 July 2001

Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because the R6 strain is avirulent and, more importantly, because it is readily transformed with DNA from homologous species and many heterologous species, it is the principal platform for investigation of the biology of this important pathogen. It is also used as a primary vehicle for genomics-based development of antibiotics for gram-positive bacteria. In our analysis of the genome, we identified a large number of new uncharacterized genes predicted to encode proteins that either reside on the surface of the cell or are secreted. Among those proteins there may be new targets for vaccine and antibiotic development.

* Corresponding author. Mailing address: Infectious Diseases Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285-0438. Phone: (317) 277-0143. Fax: (317) 276-1743. E-mail: glass_john_i{at}lilly.com.

Journal of Bacteriology, October 2001, p. 5709-5717, Vol. 183, No. 19
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.19.5709-5717.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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