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Journal of Bacteriology, October 2001, p. 5768-5771, Vol. 183, No. 19
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.19.5768-5771.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The Phosphate-Binding Protein of Escherichia coli Is Not Essential for P_i-Regulated Expression of the pho Regulon

Sally M. Hoffer and Jan Tommassen^*

Department of Molecular Microbiology and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands

Received 15 May 2001/Accepted 10 July 2001

Disruption of pstS encoding the P_i-binding protein in Escherichia coli generally leads to the constitutive expression of the pho regulon. We demonstrate that P_i-controlled expression is restored when the activity of the P_i transporter PitA or PitB is increased. Apparently, PstS is not an essential component of the signal transduction pathway.

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^* Corresponding author. Mailing address: Department of Molecular Microbiology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. Phone: (31) 30 2532999. Fax: (31) 30 2513655. E-mail: J.P.M.Tommassen{at}bio.uu.nl.

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Journal of Bacteriology, October 2001, p. 5768-5771, Vol. 183, No. 19
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.19.5768-5771.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.