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Journal of Bacteriology, January 2001, p. 768-772, Vol. 183, No. 2
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.2.768-772.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Competence Modulation by the NADH Oxidase of Streptococcus pneumoniae Involves Signal Transduction

José R. Echenique and Marie C. Trombe*

Laboratoire de Genétique et Physiologie Bactérienne, Centre Hospitalo Universitaire de Rangueil, Université Paul Sabatier, 31403 Toulouse Cedex, France

Received 27 June 2000/Accepted 16 October 2000

Oxygen controls competence development in Streptococcus pneumoniae. Oxygen signaling involves the two-component signal transduction systems CiaRH and ComDE and the competence-stimulating peptide encoded by comC and processed by ComAB. We found that NADH oxidase (Nox) was required for optimal competence. Transcriptional analysis and genetic dissection showed that Nox was involved in post-transcriptional activation of the response regulator ComE and in the transcriptional control of ciaRH and comCDE. Thus, in S. pneumoniae, Nox, with O2 as its secondary substrate, is part of the O2-signaling pathway.

* Corresponding author. Mailing address: Laboratoire de Genétique et Physiologie Bactérienne, Centre Hospitalo Universitaire de Rangueil, Université Paul Sabatier, 31403 Toulouse Cedex, France. Phone: (33)561322974. Fax: (33)561322620. E-mail: trombe{at}cict.fr.

Journal of Bacteriology, January 2001, p. 768-772, Vol. 183, No. 2
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.2.768-772.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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