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Journal of Bacteriology, February 2001, p. 1455-1458, Vol. 183, No. 4
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.4.1455-1458.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Overexpression of the Response Regulator evgA of the Two-Component Signal Transduction System Modulates Multidrug Resistance Conferred by Multidrug Resistance Transporters

Kunihiko Nishino and Akihito Yamaguchi*

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Faculty of Pharmaceutical Science, Osaka University, Suita, Osaka 565-0871, and CREST, Japan Science and Technology Corporation, Osaka 567-0047, Japan

Received 14 August 2000/Accepted 16 November 2000

Overexpression of evgA, a response regulator of a two-component system, increased multidrug efflux in Escherichia coli. Since overexpression of the emrKY operon, which is controlled by evgAS, could account only for deoxycholate resistance, the evgAS locus apparently controls expression of at least one other multidrug efflux operon.

* Corresponding author. Mailing address: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. Phone: 81-6-6879-8545. Fax: 81-6-6879-8549. E-mail: akihito{at}sanken.osaka-u.ac.jp.

Journal of Bacteriology, February 2001, p. 1455-1458, Vol. 183, No. 4
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.4.1455-1458.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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