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Journal of Bacteriology, March 2001, p. 1796-1800, Vol. 183, No. 5
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.5.1796-1800.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The miaA Mutator Phenotype of Escherichia coli K-12 Requires Recombination Functions

Jingyong Zhao, Hon-Chiu Eastwood Leung, and Malcolm E. Winkler*

Department of Microbiology and Molecular Genetics, University of Texas---Houston Medical School, Houston, Texas 77030

Received 3 October 2000/Accepted 4 December 2000

miaA mutants, which contain A-37 instead of the ms2i6A-37 hypermodification in their tRNA, show a moderate mutator phenotype leading to increased GCright-arrowTA transversion. We show that the miaA mutator phenotype is dependent on recombination functions similar to, but not exactly the same as, those required for translation stress-induced mutagenesis.

* Corresponding author. Present address: Lilly Research Laboratories, Drop Code 1543, Indianapolis, IN 46285. Phone: (317) 433-0095. Fax: (317) 276-9159. E-mail: Winkler_Malcolm_E{at}Lilly.com.

Journal of Bacteriology, March 2001, p. 1796-1800, Vol. 183, No. 5
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.5.1796-1800.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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