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Journal of Bacteriology, March 2001, p. 1824-1829, Vol. 183, No. 5
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.5.1824-1829.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Conserved Gene Cluster at Replication Origins of the alpha -Proteobacteria Caulobacter crescentus and Rickettsia prowazekii

Ann Karen C. Brassinga, Rania Siam, and Gregory T. Marczynski*

Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada

Received 27 July 2000/Accepted 13 December 2000

A 30-kb region surrounding the replication origin in Caulobacter crescentus was analyzed. Comparison to the genome sequence of another alpha -proteobacterium, Rickettsia prowazekii, revealed a conserved cluster of genes (RP001, hemE, hemH, and RP883) that overlaps the established origin of replication in C. crescentus and the putative origin of replication in R. prowazekii. The genes flanking this cluster differ between these two organisms. We therefore propose that this conserved gene cluster can be used to identify the origin of replication in other alpha -proteobacteria.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, McGill University, 3775 University St., Montreal, Quebec H3A 2B4, Canada. Phone: (514) 398-3917. Fax: (514) 398-7052. E-mail: gmarczynski{at}microimm.mcgill.ca.

Journal of Bacteriology, March 2001, p. 1824-1829, Vol. 183, No. 5
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.5.1824-1829.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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