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Journal of Bacteriology, April 2001, p. 2485-2489, Vol. 183, No. 8
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.8.2485-2489.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Ability for Anaerobic Growth Is Not Sufficient for Development of the Petite Phenotype in Saccharomyces kluyveri

Kasper Møller,1,2 Lisbeth Olsson,2 and Jure Piskur1,*

Department of Microbiology1 and Center for Process Biotechnology, Department of Biotechnology,2 Technical University of Denmark, Lyngby, Denmark

Received 26 October 2000/Accepted 29 January 2001

Saccharomyces cerevisiae is a petite-phenotype-positive ("petite-positive") yeast, which can successfully grow in the absence of oxygen. On the other hand, Kluyveromyces lactis as well as many other yeasts are petite negative and cannot grow anaerobically. In this paper, we show that Saccharomyces kluyveri can grow under anaerobic conditions, but while it can generate respiration-deficient mutants, it cannot generate true petite mutants. From a phylogenetic point of view, S. kluyveri is apparently more closely related to S. cerevisiae than to K. lactis. These observations suggest that the progenitor of the modern Saccharomyces and Kluyveromyces yeasts, as well as other related genera, was a petite-negative and aerobic yeast. Upon separation of the K. lactis and S. kluyveri-S. cerevisiae lineages, the latter developed the ability to grow anaerobically. However, while the S. kluyveri lineage has remained petite negative, the lineage leading to the modern Saccharomyces sensu stricto and sensu lato yeasts has developed the petite-positive characteristic.

* Corresponding author. Mailing address: Department of Microbiology, Building 301, Technical University of Denmark, 2800 Lyngby, Denmark. Phone: (45) 45 25 25 18. Fax:(45) 45 93 28 09. E-mail: imjp{at}pop.dtu.dk.

Journal of Bacteriology, April 2001, p. 2485-2489, Vol. 183, No. 8
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.8.2485-2489.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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