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Journal of Bacteriology, August 2002, p. 4369-4373, Vol. 184, No. 16
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.16.4369-4373.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

ZntB Is a Novel Zn2+ Transporter in Salmonella enterica Serovar Typhimurium

Ashley J. Worlock and Ronald L. Smith*

Department of Biology, The University of Texas at Arlington, Arlington, Texas 76019

Received 23 April 2002/ Accepted 31 May 2002

A Zn2+ transport system encoded by the zntB locus of Salmonella enterica serovar Typhimurium has been identified. The protein encoded by this locus is homologous to the CorA family of Mg2+ transport proteins and is widely distributed among the eubacteria. Mutations at zntB confer an increased sensitivity to the cytotoxic effects of Zn2+ and Cd2+, a phenotype that suggests that the encoded protein mediates the efflux of both cations. A direct analysis of transport activity identified a capacity for Zn2+ efflux. These data identify ZntB as a zinc efflux pathway in the enteric bacteria and assign a new function to the CorA family of cation transporters.

* Corresponding author. Mailing address: Department of Biology, The University of Texas at Arlington, Arlington, TX 76019. Phone: (817) 272-2411. Fax: (817) 272-2855. E-mail: rlsmith{at}airmail.net.

Journal of Bacteriology, August 2002, p. 4369-4373, Vol. 184, No. 16
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.16.4369-4373.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Moomaw, A. S., Maguire, M. E. (2008). The Unique Nature of Mg2+ Channels. Physiology 23: 275-285 [Abstract] [Full Text]  
  • Payandeh, J., Li, C., Ramjeesingh, M., Poduch, E., Bear, C. E., Pai, E. F. (2008). Probing Structure-Function Relationships and Gating Mechanisms in the CorA Mg2+ Transport System. J. Biol. Chem. 283: 11721-11733 [Abstract] [Full Text]  
  • Eshaghi, S., Niegowski, D., Kohl, A., Molina, D. M., Lesley, S. A., Nordlund, P. (2006). Crystal Structure of a Divalent Metal Ion Transporter CorA at 2.9 Angstrom Resolution.. Science 313: 354-357 [Abstract] [Full Text]  
  • Caldwell, A. M., Smith, R. L. (2003). Membrane Topology of the ZntB Efflux System of Salmonella enterica Serovar Typhimurium. J. Bacteriol. 185: 374-376 [Abstract] [Full Text]  


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