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Journal of Bacteriology, February 2002, p. 1089-1094, Vol. 184, No. 4
0021-9193/01/$04.00+0     DOI: 10.1128/jb.184.4.1089-1094.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Microviridae, a Family Divided: Isolation, Characterization, and Genome Sequence of {phi}MH2K, a Bacteriophage of the Obligate Intracellular Parasitic Bacterium Bdellovibrio bacteriovorus

Karie L. Brentlinger,1 Susan Hafenstein,1 Christopher R. Novak,1 Bentley A. Fane,1* Robert Borgon,2 Robert McKenna,2 and Mavis Agbandje-McKenna2

Department of Veterinary Sciences and Microbiology, University of Arizona, Tucson, Arizona,1 Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida2

Received 11 September 2001/ Accepted 11 November 2001

A novel single-stranded DNA phage, {phi}MH2K, of Bdellovibrio bacteriovorus was isolated, characterized, and sequenced. This phage is a member of the Microviridae, a family typified by bacteriophage {phi}X174. Although B. bacteriovorus and Escherichia coli are both classified as proteobacteria, {phi}MH2K is only distantly related to {phi}X174. Instead, {phi}MH2K exhibits an extremely close relationship to the Microviridae of Chlamydia in both genome organization and encoded proteins. Unlike the double-stranded DNA bacteriophages, for which a wide spectrum of diversity has been observed, the single-stranded icosahedral bacteriophages appear to fall into two distinct subfamilies. These observations suggest that the mechanisms driving single-stranded DNA bacteriophage evolution are inherently different from those driving the evolution of the double-stranded bacteriophages.

* Corresponding author. Mailing address: Department of Veterinary Sciences and Microbiology, Building 90, University of Arizona, Tucson, AZ 85721-0900. Phone: (520) 626-6634. Fax: (520) 621-6366. E-mail: bfane{at}u.arizona.edu.

Journal of Bacteriology, February 2002, p. 1089-1094, Vol. 184, No. 4
0021-9193/01/$04.00+0     DOI: 10.1128/jb.184.4.1089-1094.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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