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Journal of Bacteriology, March 2002, p. 1462-1465, Vol. 184, No. 5
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.5.1462-1465.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Mapping of Myxococcus xanthus Social Motility dsp Mutations to the dif Genes

*** Hope Lancero,1 Jennifer E. Brofft,2 John Downard,3 Bruce W. Birren,4 Chad Nusbaum,4 Jerome Naylor,4 Wenyuan Shi,1 and Lawrence J. Shimkets2*

Molecular Biology Institute and School of Dentistry, University of California, Los Angeles, Los Angeles, California 90095-1668,1 Department of Microbiology, University of Georgia, Athens, Georgia 30602-2605,2 Department of Botany and Microbiology, University of Oklahoma, Norman, Oklahoma 73019-6131,3 Whitehead Institute/MIT Center for Genome Research, Cambridge, Massachusetts 021414

Received 8 August 2001/ Accepted 7 December 2001

Myxococcus xanthus dsp and dif mutants have similar phenotypes in that they are deficient in social motility and fruiting body development. We compared the two loci by genetic mapping, complementation with a cosmid clone, DNA sequencing, and gene disruption and found that 16 of the 18 dsp alleles map to the dif genes. Another dsp allele contains a mutation in the sglK gene. About 36.6 kb around the dsp-dif locus was sequenced and annotated, and 50% of the genes are novel.

* Corresponding author. Mailing address: Department of Microbiology, University of Georgia, Athens, GA 30602-2605. Phone: (706) 542-2681. Fax: (706) 542-2674. E-mail: shimkets{at}arches.uga.edu.

Journal of Bacteriology, March 2002, p. 1462-1465, Vol. 184, No. 5
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.5.1462-1465.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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