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Journal of Bacteriology, August 2003, p. 4626-4629, Vol. 185, No. 15
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.15.4626-4629.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Competition between MutY and Mismatch Repair at A · C Mispairs In Vivo

Mandy Kim, Tiffany Huang, and Jeffrey H. Miller*

Department of Microbiology, Immunology, and Molecular Genetics and The Molecular Biology Institute, University of California, Los Angeles, California 90095

Received 3 March 2003/ Accepted 8 May 2003

We show that the MutY protein competes with the MutS-dependent mismatch repair system to process at least some A · C mispairs in vivo, converting them to G · C pairs. In the presence of an increased dCTP pool resulting from the loss of nucleotide diphosphate kinase, the frequency of A · T->G · C transitions at a hot spot in the rpoB gene is 30-fold lower in a MutY-deficient derivative than in the wild type.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Molecular Genetics, UCLA, 405 Hilgard Ave., Los Angeles, CA 90095. Phone: (310) 825-8460. Fax: (310) 206-3088. E-mail: jhmiller{at}mbi.ucla.edu.

Journal of Bacteriology, August 2003, p. 4626-4629, Vol. 185, No. 15
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.15.4626-4629.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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