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Journal of Bacteriology, November 2003, p. 6472-6476, Vol. 185, No. 21
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.21.6472-6476.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

A Transcriptional Pause Synchronizes Translation with Transcription in the Tryptophanase Operon Leader Region

Feng Gong{dagger} and Charles Yanofsky*

Department of Biological Sciences, Stanford University, Stanford, California 94305-5020

Received 16 June 2003/ Accepted 12 August 2003

Regulation of transcription of the tryptophanase operon requires that translation of its leader peptide coding region, tnaC, be coupled with its transcription. We show in vitro that a transcription pause site exists at the end of the tnaC coding region and that translation of tnaC releases the paused transcription complex, coupling transcription with translation.

* Corresponding author. Mailing address: Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020. Phone: (650) 723-1835. Fax: (650) 725-8221. E-mail: yanofsky{at}cmgm.stanford.edu.

{dagger} Present address: Department of Biochemistry and Biophysics, Washington State University, Pullman, WA 99164-4660.

Journal of Bacteriology, November 2003, p. 6472-6476, Vol. 185, No. 21
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.21.6472-6476.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cruz-Vera, L. R., Yang, R., Yanofsky, C. (2009). Tryptophan Inhibits Proteus vulgaris TnaC Leader Peptide Elongation, Activating tna Operon Expression. J. Bacteriol. 191: 7001-7006 [Abstract] [Full Text]  
  • Stewart, V. (2008). The Ribosome: a Metabolite-Responsive Transcription Regulator. J. Bacteriol. 190: 4787-4790 [Full Text]  
  • Grundy, F. J., Henkin, T. M. (2004). Kinetic Analysis of tRNA-Directed Transcription Antitermination of the Bacillus subtilis glyQS Gene In Vitro. J. Bacteriol. 186: 5392-5399 [Abstract] [Full Text]  


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