This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Giladi, M.
Right arrow Articles by Mevarech, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giladi, M.
Right arrow Articles by Mevarech, M.

 Previous Article  |  Next Article 

Journal of Bacteriology, December 2003, p. 7015-7018, Vol. 185, No. 23
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.23.7015-7018.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli

Moshe Giladi, Neta Altman-Price, Itay Levin, Liat Levy, and Moshe Mevarech*

Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

Received 27 May 2003/ Accepted 2 September 2003

Escherichia coli (thyA {Delta}folA) mutants are viable and can grow in minimal medium when supplemented with thymidine alone. Here we present evidence from in vivo and in vitro studies that the ydgB gene determines an alternative dihydrofolate reductase that is related to the trypanosomatid pteridine reductases. We propose to rename this gene folM.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel. Phone: 972-3-6408715. Fax: 972-3-6409407. E-mail: mevarech{at}post.tau.ac.il.

Journal of Bacteriology, December 2003, p. 7015-7018, Vol. 185, No. 23
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.23.7015-7018.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Brochet, M., Couve, E., Zouine, M., Poyart, C., Glaser, P. (2008). A Naturally Occurring Gene Amplification Leading to Sulfonamide and Trimethoprim Resistance in Streptococcus agalactiae. J. Bacteriol. 190: 672-680 [Abstract] [Full Text]  
  • Leduc, D., Escartin, F., Nijhout, H. F., Reed, M. C., Liebl, U., Skouloubris, S., Myllykallio, H. (2007). Flavin-Dependent Thymidylate Synthase ThyX Activity: Implications for the Folate Cycle in Bacteria. J. Bacteriol. 189: 8537-8545 [Abstract] [Full Text]  
  • Levin, I., Mevarech, M., Palfey, B. A. (2007). Characterization of a Novel Bifunctional Dihydropteroate Synthase/Dihydropteroate Reductase Enzyme from Helicobacter pylori. J. Bacteriol. 189: 4062-4069 [Abstract] [Full Text]  
  • Noiriel, A., Naponelli, V., Gregory, J. F. III, Hanson, A. D. (2007). Pterin and Folate Salvage. Plants and Escherichia coli Lack Capacity to Reduce Oxidized Pterins. Plant Physiol. 143: 1101-1109 [Abstract] [Full Text]  
  • El Yacoubi, B., Bonnett, S., Anderson, J. N., Swairjo, M. A., Iwata-Reuyl, D., de Crecy-Lagard, V. (2006). Discovery of a New Prokaryotic Type I GTP Cyclohydrolase Family. J. Biol. Chem. 281: 37586-37593 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»