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Journal of Bacteriology, February 2003, p. 1462-1464, Vol. 185, No. 4
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.4.1462-1464.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Identification and Characterization of the gerH Operon of Bacillus anthracis Endospores: a Differential Role for Purine Nucleosides in Germination

Matthew A. Weiner,1 Timothy D. Read,2 and Philip C. Hanna1*

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan,1 The Institute for Genomic Research, Rockville, Maryland2

Received 19 August 2002/ Accepted 18 November 2002

We identified a tri-cistronic operon, gerH, in Bacillus anthracis that is important for endospore germination triggered by two distinct germination response pathways termed inosine-His and purine-Ala. Together, the two pathways allow B. anthracis endospores a broader recognition of purines and amino acids that may be important for host-mediated germination.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Med. Sci. II, Box 0620, Ann Arbor, MI 48104. Phone: (734) 615-3706. Fax: (734) 764-3562. E-mail: pchanna{at}umich.edu.

Journal of Bacteriology, February 2003, p. 1462-1464, Vol. 185, No. 4
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.4.1462-1464.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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