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Journal of Bacteriology, March 2003, p. 2031-2035, Vol. 185, No. 6
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.6.2031-2035.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Measurement of Adhesive Forces between Individual Staphylococcus aureus MSCRAMMs and Protein-Coated Surfaces by Use of Optical Tweezers

Kathryn H. Simpson,1 Gabriela Bowden,2 Magnus Höök,2 and Bahman Anvari1*

Department of Bioengineering, Rice University, Houston, Texas 77251-1892,1 Center for Extracellular Matrix Biology, Albert B. Alkek Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 770302

Received 5 September 2002/ Accepted 20 December 2002

The force required to rupture bonds between individual Staphylococcus aureus MSCRAMMs and surfaces coated with extracellular matrix molecules has been quantified by using optical tweezers. The observed binding forces between fibrinogen or fibronectin and S. aureus MSCRAMMs occurred as an approximate integer multiple of 20 or 25 pN, respectively.

* Corresponding author. Mailing address: Department of Bioengineering, Rice University, P.O. Box 1892, MS 142, Houston, Texas 77251-1892. Phone: (713) 348-5870. Fax: (713) 348-5877. E-mail: anvari{at}rice.edu.

Journal of Bacteriology, March 2003, p. 2031-2035, Vol. 185, No. 6
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.6.2031-2035.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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  • Kropec, A., Maira-Litran, T., Jefferson, K. K., Grout, M., Cramton, S. E., Gotz, F., Goldmann, D. A., Pier, G. B. (2005). Poly-N-Acetylglucosamine Production in Staphylococcus aureus Is Essential for Virulence in Murine Models of Systemic Infection. Infect. Immun. 73: 6868-6876 [Abstract] [Full Text]  


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