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Journal of Bacteriology, April 2003, p. 2667-2672, Vol. 185, No. 8
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.8.2667-2672.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Global Analysis of Genes Regulated by EvgA of the Two-Component Regulatory System in Escherichia coli

Kunihiko Nishino,1,2,3 Yoshihiko Inazumi,1,3 and Akihito Yamaguchi1,2,3*

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki,1 Core Research for Evolution Science and Technology, Japan Science and Technology Corporation, Osaka 567-0047,2 Faculty of Pharmaceutical Science, Osaka University, Suita, Osaka 565-0871, Japan3

Received 22 August 2002/ Accepted 28 January 2003

The response regulator EvgA controls expression of multiple genes conferring antibiotic resistance in Escherichia coli (K. Nishino and A. Yamaguchi, J. Bacteriol. 184:2319-2323, 2002). To understand the whole picture of EvgA regulation, DNA macroarray analysis of the effect of EvgA overproduction was performed. EvgA activated genes related to acid resistance, osmotic adaptation, and drug resistance.


* Corresponding author. Mailing address: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. Phone: 81-6-6879-8545. Fax: 81-6-6879-8549. E-mail: akihito{at}sanken.osaka-u.ac.jp.


Journal of Bacteriology, April 2003, p. 2667-2672, Vol. 185, No. 8
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.8.2667-2672.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.




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