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Journal of Bacteriology, May 2004, p. 3259-3261, Vol. 186, No. 10
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.10.3259-3261.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lipid II-Mediated Pore Formation by the Peptide Antibiotic Nisin: a Black Lipid Membrane Study

Imke Wiedemann,1* Roland Benz,2 and Hans-Georg Sahl1

Institut für Medizinische Mikrobiologie und Immunologie der Universität Bonn, D-53105 Bonn,1 Lehrstuhl für Biotechnologie (Biozentrum), D-97074 Würzburg, Germany2

Received 27 November 2003/ Accepted 4 February 2004

The antibiotic peptide nisin is the first known lantibiotic that uses a docking molecule within the bacterial cytoplasmic membrane for pore formation. Through specific interaction with the cell wall precursor lipid II, nisin forms defined pores which are stable for seconds and have pore diameters of 2 to 2.5 nm.

* Corresponding author. Mailing address: Institut für Medizinische Mikrobiologie und Immunologie der Universität Bonn, Sigmund-Freud Str. 25, 53105 Bonn, Germany. Phone: 49 (228) 287 6483. Fax: 49 (228) 287 4808. E-mail: imke.wiedemann{at}ukb.uni-bonn.de.

Journal of Bacteriology, May 2004, p. 3259-3261, Vol. 186, No. 10
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.10.3259-3261.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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