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Journal of Bacteriology, May 2004, p. 3278-3281, Vol. 186, No. 10
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.10.3278-3281.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Phage Protein Confers Resistance to the Lactococcal Abortive Infection Mechanism AbiP

Susana Domingues, Alain Chopin, S. Dusko Ehrlich, and Marie-Christine Chopin*

Laboratoire de Génétique Microbienne, INRA, 78352 Jouy-en-Josas, France

Received 29 October 2003/ Accepted 2 February 2004

Phage bIL66M1 is sensitive to the lactococcal abortive infection mechanism AbiP. No spontaneous AbiP-resistant variant could be obtained at a frequency of <10–10. However, AbiP-resistant variants were readily obtained during infection with both bIL66M1 and the highly homologous AbiP-resistant phage bIL170. Gain of AbiP resistance was due to the acquisition of the e6 gene from bIL170.

* Corresponding author. Mailing address: Laboratoire de Génétique Microbienne, INRA, 78352 Jouy-en-Josas, France. Phone: 33 1 34 65 25 30. Fax: 33 1 34 65 25 21. E-mail: mchopin{at}jouy.inra.fr.

Journal of Bacteriology, May 2004, p. 3278-3281, Vol. 186, No. 10
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.10.3278-3281.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Labrie, S. J., Moineau, S. (2007). Abortive Infection Mechanisms and Prophage Sequences Significantly Influence the Genetic Makeup of Emerging Lytic Lactococcal Phages. J. Bacteriol. 189: 1482-1487 [Abstract] [Full Text]  
  • Rakonjac, J., O'Toole, P. W., Lubbers, M. (2005). Isolation of Lactococcal Prolate Phage-Phage Recombinants by an Enrichment Strategy Reveals Two Novel Host Range Determinants. J. Bacteriol. 187: 3110-3121 [Abstract] [Full Text]  


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