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 Previous Article

Journal of Bacteriology, June 2004, p. 4046-4050, Vol. 186, No. 12
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.12.4046-4050.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Microarray Analysis and Functional Characterization of the Nitrosative Stress Response in Nonmucoid and Mucoid Pseudomonas aeruginosa{dagger}

Aaron M. Firoved,1 Simon R. Wood,2,3 Wojciech Ornatowski,1 Vojo Deretic,1 and Graham S. Timmins2*

Department of Molecular Genetics and Microbiology,1 College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131,2 Division of Oral Biology, Leeds Dental Institute, University of Leeds, Leeds, United Kingdom3

Received 4 September 2003/ Accepted 2 March 2004

The type strain of Pseudomonas aeruginosa, PAO1, showed great upregulation of many nitrosative defense genes upon treatment with S-nitrosoglutathione, while the mucoid strain PAO578II showed no further upregulation above its constitutive upregulation of nor and fhp. NO· consumption however, showed that both strains mount functional, protein synthesis-dependent NO·-consumptive responses.

* Corresponding author. Mailing address: College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, NM 87131. Phone: (505) 272-4103. Fax: (505) 272-6749. E-mail: gtimmins{at}salud.unm.edu.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, June 2004, p. 4046-4050, Vol. 186, No. 12
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.12.4046-4050.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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