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Journal of Bacteriology, September 2004, p. 6332-6334, Vol. 186, No. 18
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.18.6332-6334.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Extensive Genomic Polymorphism within Mycobacterium avium{dagger}

Makeda Semret,1 Gary Zhai,1 Serge Mostowy,1 Cynthia Cleto,1 David Alexander,1 Gerard Cangelosi,2 Debby Cousins,3 Desmond M. Collins,4 Dick van Soolingen,5 and Marcel A. Behr1*

McGill University Health Centre, Montreal, Canada,1 Seattle Biomedical Research Institute, Seattle, Washington,2 Australian Reference Laboratory for Bovine Tuberculosis, Department of Agriculture, South Perth, Australia,3 AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand,4 National Institute of Public Health and the Environment, Bilthoven, The Netherlands5

Received 27 January 2004/ Accepted 27 June 2004

We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.

* Corresponding author. Mailing address: Division of Infectious Diseases and Medical Microbiology, A5-156, Montreal General Hospital, 1650 Cedar Ave., Montreal, Quebec H3G 1A4, Canada. Phone: (514) 934-1934, ext. 42815. Fax: (514) 934-8423. E-mail: marcel.behr{at}mcgill.ca.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, September 2004, p. 6332-6334, Vol. 186, No. 18
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.18.6332-6334.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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