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Journal of Bacteriology, April 2004, p. 2215-2220, Vol. 186, No. 7
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.7.2215-2220.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The PaaX Repressor, a Link between Penicillin G Acylase and the Phenylacetyl-Coenzyme A Catabolon of Escherichia coli W

Beatriz Galán, José L. García, and María A. Prieto*

Department of Molecular Microbiology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

Received 21 October 2003/ Accepted 30 December 2003

The pac gene, encoding the penicillin G acylase from Escherichia coli W, is regulated by the PaaX repressor of the phenylacetate catabolic pathway. pac expression depends on the synthesis of phenylacetyl-coenzyme A. PaaX and the cyclic AMP receptor protein (CRP) bind in vitro to the Ppac promoter region. A palindromic sequence proposed as the PaaX operator is located upstream of the –35 box overlapping a CRP binding site, an unusual position that suggests a novel regulatory mechanism.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain. Phone: 34-918373112. Fax: 34-915360432. E-mail: auxi{at}cib.csic.es.

Journal of Bacteriology, April 2004, p. 2215-2220, Vol. 186, No. 7
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.7.2215-2220.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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