This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reguera, G.
Right arrow Articles by Kolter, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reguera, G.
Right arrow Articles by Kolter, R.

 Previous Article  |  Next Article 

Journal of Bacteriology, May 2005, p. 3551-3555, Vol. 187, No. 10
0021-9193/05/$08.00+0     doi:10.1128/JB.187.10.3551-3555.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Virulence and the Environment: a Novel Role for Vibrio cholerae Toxin-Coregulated Pili in Biofilm Formation on Chitin

Gemma Reguera* and Roberto Kolter

Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115

Received 28 November 2004/ Accepted 28 January 2005

The toxin-coregulated pilus (TCP) of Vibrio cholerae is required for intestinal colonization and cholera toxin acquisition. Here we report that TCP mediates bacterial interactions required for biofilm differentiation on chitinaceous surfaces. We also show that undifferentiated TCP– biofilms have reduced ecological fitness and, thus, that chitin colonization may represent an ecological setting outside the host in which selection for a host colonization factor may take place.

* Corresponding author. Present address: Department of Microbiology, 203 Morrill Science Ctr. IV-N, University of Massachusetts, Amherst, MA 01003. Phone: (413) 577-1745. Fax: (413) 545-1578. E-mail: greguera{at}microbio.umass.edu.

Journal of Bacteriology, May 2005, p. 3551-3555, Vol. 187, No. 10
0021-9193/05/$08.00+0     doi:10.1128/JB.187.10.3551-3555.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gu, J., Wang, Y., Lilburn, T. (2009). A Comparative Genomics, Network-Based Approach to Understanding Virulence in Vibrio cholerae. J. Bacteriol. 191: 6262-6272 [Abstract] [Full Text]  
  • Xicohtencatl-Cortes, J., Monteiro-Neto, V., Saldana, Z., Ledesma, M. A., Puente, J. L., Giron, J. A. (2009). The Type 4 Pili of Enterohemorrhagic Escherichia coli O157:H7 Are Multipurpose Structures with Pathogenic Attributes. J. Bacteriol. 191: 411-421 [Abstract] [Full Text]  
  • Hunt, D. E., Gevers, D., Vahora, N. M., Polz, M. F. (2008). Conservation of the Chitin Utilization Pathway in the Vibrionaceae. Appl. Environ. Microbiol. 74: 44-51 [Abstract] [Full Text]  
  • Matson, J. S., Withey, J. H., DiRita, V. J. (2007). Regulatory Networks Controlling Vibrio cholerae Virulence Gene Expression. Infect. Immun. 75: 5542-5549 [Full Text]  
  • Paranjpye, R. N., Johnson, A. B., Baxter, A. E., Strom, M. S. (2007). Role of Type IV Pilins in Persistence of Vibrio vulnificus in Crassostrea virginica Oysters. Appl. Environ. Microbiol. 73: 5041-5044 [Abstract] [Full Text]  
  • Fong, J. C. N., Yildiz, F. H. (2007). The rbmBCDEF Gene Cluster Modulates Development of Rugose Colony Morphology and Biofilm Formation in Vibrio cholerae. J. Bacteriol. 189: 2319-2330 [Abstract] [Full Text]  
  • Reguera, G., Pollina, R. B., Nicoll, J. S., Lovley, D. R. (2007). Possible Nonconductive Role of Geobacter sulfurreducens Pilus Nanowires in Biofilm Formation. J. Bacteriol. 189: 2125-2127 [Abstract] [Full Text]  
  • Rohmer, L., Brittnacher, M., Svensson, K., Buckley, D., Haugen, E., Zhou, Y., Chang, J., Levy, R., Hayden, H., Forsman, M., Olson, M., Johansson, A., Kaul, R., Miller, S. I. (2006). Potential Source of Francisella tularensis Live Vaccine Strain Attenuation Determined by Genome Comparison. Infect. Immun. 74: 6895-6906 [Abstract] [Full Text]  
  • Rollenhagen, J. E., Kalsy, A., Cerda, F., John, M., Harris, J. B., LaRocque, R. C., Qadri, F., Calderwood, S. B., Taylor, R. K., Ryan, E. T. (2006). Transcutaneous Immunization with Toxin-Coregulated Pilin A Induces Protective Immunity against Vibrio cholerae O1 El Tor Challenge in Mice.. Infect. Immun. 74: 5834-5839 [Abstract] [Full Text]  
  • Faruque, S. M., Biswas, K., Udden, S. M. N., Ahmad, Q. S., Sack, D. A., Nair, G. B., Mekalanos, J. J. (2006). Transmissibility of cholera: In vivo-formed biofilms and their relationship to infectivity and persistence in the environment. Proc. Natl. Acad. Sci. USA 103: 6350-6355 [Abstract] [Full Text]  
  • Fong, J. C. N., Karplus, K., Schoolnik, G. K., Yildiz, F. H. (2006). Identification and Characterization of RbmA, a Novel Protein Required for the Development of Rugose Colony Morphology and Biofilm Structure in Vibrio cholerae. J. Bacteriol. 188: 1049-1059 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»